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PF 04628935

Catalog #: 6347 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6347/5
6347/25
PF 04628935 | CAS No. 1383719-97-8 | Ghrelin Receptor Inverse Agonists
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Description: Potent ghrelin receptor inverse agonist

Chemical Name: 1-[2-[[2-Chloro-4-(2H-1,2,3-triazol-2-yl)phenyl]methyl]-2,7-diazaspiro[3.5]non-7-yl]-2-(2-methylimidazo[2,1-b]thiazol-6-yl)ethanone

Purity: ≥98%

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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

PF 04628935 is a potent ghrelin receptor inverse agonist (IC50 = 4.6 nM). Orally bioavailable and exhibits reasonable brain penetration.

Technical Data

M.Wt:
496.03
Formula:
C24H26ClN7OS
Solubility:
Soluble to 50 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1383719-97-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Background References

  1. Identification of spirocyclic piperidine-azetidine inverse agonists of the ghrelin receptor.
    Kung et al.
    Bioorg.Med.Chem.Lett., 2012;22:5410

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