PD 161570
Chemical Name: N-[6-(2,6-Dichlorophenyl)-2-[[4-(diethylamino)butyl]amino]pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea
Purity: ≥97%
Biological Activity
PD 161570 is a selective FGFR inhibitor (IC50 values are 40, 262 and 3700 nM for FGFR, PDGFR and EGFR respectively). Inhibits FGFR receptor phosphorylation (IC50 = 622 nM) and growth of A121 cells in vitro.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Structure-activity relationships for a novel series of pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors.
Hamby et al.
J.Med.Chem., 1997;40:2296 -
Inhibition of FGF-1 receptor tyrosine kinase activity by PD 161570, a new protein-tyrosine kinase inhibitor.
Batley et al.
Life Sci., 1998;62:143
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Citations for PD 161570
The citations listed below are publications that use Tocris products. Selected citations for PD 161570 include:
3 Citations: Showing 1 - 3
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Regulation of NF-kB Signalling Through the PR55β-RelA Interaction in Osteoblasts.
Authors: Tomohiro Et al.
In Vivo 2020;34:601-608
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Paracrine effects of embryo-derived FGF4 and BMP4 during pig trophoblast elongation.
Authors: Magaña Et al.
Dev Biol 2014;387:15
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Modulation of pluripotency in the porcine embryo and iPS cells.
Authors: Rodríguez Et al.
J Exp Bot 2012;7:e49079
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