PD 150606
Chemical Name: (Z)-3-(4-Iodophenyl)-2-mercapto-2-propenoic acid
Purity: ≥95%
Biological Activity
PD 150606 is a selective, cell-permeable non-peptide calpain inhibitor (Ki values for ν and m-calpains are 0.21 and 0.37 μM respectively). Targets the calcium binding sites of calpain. Demonstrates high specificity for calpains relative to other proteases, and is a non-competitive inhibitor with respect to the substrate.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Production and regulation of interleukin-1 family cytokines at the materno-fetal interface
LM Scott, AH Bryant, A Rees, B Down, RH Jones, CA Thornton
Cytokine, 2017;0(0):. -
Calpain and calpastatin regulate neutrophil apoptosis.
Squier et al.
J.Cell Physiol., 1999;178:311 -
An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective.
Wang et al.
Proc.Natl.Acad.Sci.U.S.A., 1996;93:6687 -
Calpains mediate calcium chloride influx during the late phase of cell injury.
Waters et al.
J.Pharmacol.Exp.Ther., 1997;283:1177
Product Datasheets
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Citations for PD 150606
The citations listed below are publications that use Tocris products. Selected citations for PD 150606 include:
6 Citations: Showing 1 - 6
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Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery.
Authors: Chang Et al.
Elife 2017;6
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The C-Box Region of MAF1 Regulates Transcriptional Activity and Protein Stability.
Authors: Pradhan Et al.
J Mol Biol 2017;429:192
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Thrombin-induced calpain activation promotes protease-activated receptor 1 internalization.
Authors: Alvarez-Arce
Int J Cell Biol 2017;2017:1908310
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Two proteolytic fragments of menin coordinate the nuclear transcription and postsynaptic clustering of neurotransmitter receptors during synaptogenesis between Lymnaea neurons.
Authors: Getz Et al.
Sci Rep 2016;6:31779
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ANO1 interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer.
Authors: Bill Et al.
PLoS One 2015;6:9173
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Activity-dependent regulation of the K/Cl transporter KCC2 membrane diffusion, clustering, and function in hippocampal neurons.
Authors: Chamma Et al.
J Neurosci 2013;33:15488
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