PARPi-FL

Catalog #: 6461 Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
6461/1

PARPi-FL | CAS No. 1380359-84-1 | Poly(ADP-ribose) Polymerase Inhibitors

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Description: Potent fluorescent PARP inhibitor; cell permeable

Alternative Names: AZD2281-BDY FL,Olaparib-BDY FL

Chemical Name: (T-4)-[4-[[3-[[4-[3-[5-[(3,5-Dimethyl-2H-pyrrol-2-ylidene-κN)methyl]-1H-pyrrol-2-yl-κN-1-oxopropyl]-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2H)-phthalazinonato]difluoroboron

Purity: ≥90%

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Biological Activity

PARPi-FL is a fluorescent potent PARP inhibitor (IC₅₀ = 12 nM). Composed of a PARP inhibitor conjugated to BDY FL, SE (Cat. No. 5465). Colocalizes with PARP immunostaining in multiple cancer cell lines in vivo and accumulates in tumor cells and tumor associated macrophages. Enables high temporal and subcellular spatial resolution of drug distribution. Emission max = 525 nm. Cell permeable.

Optical Data for PARPi-FL

Emission Color	Green
λ_abs	502 nm
λ_em	510 nm

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Technical Data

M.Wt:

640.46

Formula:

C₃₄H₃₂BF₃N₆O₃

Solubility:

Soluble to 10 mM in DMSO

Purity:

≥90%

Storage:

Store at -20°C

CAS No:

1380359-84-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Quantitating drug-target engagement in single cells in vitro and in vivo.
Dubach et al.
Nat.Chem.Biol., 2017;13:168
Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo.
Thurber et al.
Nat.Commun., 2013;4:1504
Effect of small-molecule modification on single-cell pharmacokinetics of PARP inhibitors.
Thurber et al.
Mol.Cancer Ther., 2014;13:986

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