PAC 1

Catalog # Availability Size / Price Qty
2581/10
2581/50
PAC 1 | CAS No. 315183-21-2 | Caspase Activators
1 Image
Description: Activator of procaspase-3; pro-apoptotic

Chemical Name: 4-(Phenylmethyl)-1-piperazineacetic acid [[2-hydroxy-3-(2-propenyl)phenyl]methylene]hydrazide

Purity: ≥98%

Product Details
Citations (2)
Reviews

Biological Activity

PAC 1 is a procaspase-activating compound; activates procaspase-3 to produce caspase-3 (EC50 = 0.22 μM). Also activates procaspase-7 in a less efficient manner (EC50 = 4.5 μM). Pro-apoptotic; induces apoptosis in both cancerous and non-cancerous cells dependent on procaspase-3 concentration (IC50 values are 0.003 - 1.41 and 5.02 - 9.98 μM respectively).

Technical Data

M.Wt:
392.5
Formula:
C23H28N4O2
Solubility:
Soluble to 75 mM in 1eq. HCl and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
315183-21-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for PAC 1

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