P110

Catalog #: 6897 Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
6897/1

1 Image

Description: Dynamin-related protein 1 (Drp1) inhibitor; cell-permeable

Purity: ≥95%

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Biological Activity

P110 is a dynamin-related protein 1 (Drp1) inhibitor, inhibits Drp1 GTPase activity. Displays no effect on dynamin 1 or other mitochondrial dynamics-related proteins. Inhibits mitochondrial fission, dysfunction and reactive oxygen species (ROS) production in vitro. Reduces programmed cell death and improves cell viability by protecting mitochondrial integrity. Reduces mitochondrial fragmentation and mitochondrial ROS production in mouse model of Parkinson's disease. Cell permeable.

Technical Data

M.Wt:

2411.8

Formula:

C₁₀₀H₁₇₉N₄₅O₂₅

Sequence:

YGRKKRRQRRRGGDLLPRGS

(Modification: Ser-20 = C-terminal amide)

Solubility:

Soluble to 1 mg/ml in water

Purity:

≥95%

Storage:

Store at -20°C

CAS No:

2770267-63-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity.
Qi X, Qvit N, Su YC, Mochly-Rosen D.
J Cell Sci.
Inhibition of Drp1 mitochondrial translocation provides neural protection in dopaminergic system in a Parkinson's disease model induced by MPTP.
Filichia et al.
Sci.Rep., 2016;13:32656

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