P-3FAX-Neu5Ac
Chemical Name: 5-(acetylamino)-3,5-dideoxy-3-fluoro-D-erythro-α-L-manno-2-nonulopyranosonic acid methyl ester 2,4,7,8,9-pentaacetate
Purity: ≥97%
Biological Activity
P-3FAX-Neu5Ac is a cell-permeable sialic acid analog. Deacetylation occurs intracellularly giving rise to a sialyltransferase inhibitor. Abolishes expression of SLex expression on HL-60 cells and reduces E-selectin and P-selectin binding. Prevents metastasis formation in a mouse lung metastasis model.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Targeted delivery of a sialic acid-blocking glycomimetic to cancer cells inhibits metastatic spread.
Büll et al.
ACS Nano., 2015;9:733 -
Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycome.
Rillahan et al.
Nat.Chem.Biol., 2012;8:661
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