OXF BD 02
Chemical Name: 3-(3,5-Dimethyl-4-isoxazolyl)-5-hydroxy-α-phenylbenzenemethanol
Purity: ≥98%
Biological Activity
OXF BD 02 is a selective inhibitor of the first bromodomain of BRD4 (BRD4(1)) (IC50 = 382 nM). Exhibits 2-3-fold selectivity for BRD4(1) over the CBP bromodomain and has little affinity for a range of other bromodomains. Reduces viability of lung adenocarcinoma cell lines and attenuates proliferation of MV-4-11 leukemia cells. Cell permeable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands.
Hewings et al.
J.Med.Chem., 2011;54:6761 -
Optimization of 3,5-dimethylisoxazole derivatives as potent bromodomain ligands.
Hewings et al.
J.Med.Chem., 2013;56:3217
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