OSU 03012

Catalog # Availability Size / Price Qty
5682/10
5682/50
OSU 03012 | CAS No. 742112-33-0 | PDK-1 Inhibitors
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Description: PDPK1 (PDK1) inhibitor; inhibits Akt signaling

Chemical Name: 2-Amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]acetamide

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

OSU 03012 is a PDPK1 (PDK1) inhibitor; inhibits Akt signaling. Induces apoptosis of PC-3 and medulloblastoma cells, and inhibits growth of a number of tumor cell lines. Sensitizes radiotherapy-induced cell death and enhances cytotoxic effects of chemotherapeutic agents in vitro. Attenuates tumor growth of medulloblastoma xenografts in mice.

Technical Data

M.Wt:
460.45
Formula:
C26H19F3N4O
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
742112-33-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for OSU 03012

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