Orexin B (mouse)

Catalog #: 1457
3 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
1457/500U

1 Image

Description: Endogenous agonist at OX1 and OX2

Purity: ≥95%

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Product Details

Citations (3)

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Orexin B (mouse) is an endogenous agonist at orexin receptors. May be involved in the regulation of feeding, sleep-wake cycle and other hypothalamic functions. Orexin B exerts excitatory effects on nigral dopaminergic neurons and alleviates motor symptoms in a Parkinson's disease mouse model.

Technical Data

M.Wt:

2936.43

Formula:

C₁₂₆H₂₁₅N₄₅O₃₄S

Sequence:

RPGPPGLQGRLQRLLQANGNHAAGILTM

(Modification: Met-28 = C-terminal amide)

Solubility:

Soluble to 1 mg/ml in water

Purity:

≥95%

Storage:

Store at -20°C

CAS No:

202801-92-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders.
Kilduff and Peyron
TiNS, 2000;23:359
Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour.
Sakurai et al.
Cell, 1998;92:573
Orexins: a new family of neuropeptides.
Smart
Br.J.Anaesth., 1999;83:695

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Citations for Orexin B (mouse)

The citations listed below are publications that use Tocris products. Selected citations for Orexin B (mouse) include:

3 Citations: Showing 1 - 3

Orexin-B exerts excitatory effects on nigral dopaminergic neurons and alleviates motor disorders in MPTP parkinsonian mice
Authors: Bian Et al.
Neurosci Lett 2021;765:136291
OX2R activation induces PKC-mediated ERK and CREB phosphorylation.
Authors: Guo and Feng
Exp Cell Res 2012;318:2004
Orexin 1 receptor activation attenuates neurogenic dural vasodilation in an animal model of trigeminovascular nociception.
Authors: Holland Et al.
J Biol Chem 2005;315:1380

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