Olmesartan
Chemical Name: 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid
Purity: ≥99%
Biological Activity
Olmesartan is a potent angiotensin II type I (AT1) receptor antagonist (IC50 = 6.7 nM at hAT1 receptors). Improves cognitive function in a mouse model of hypertension- and hyperlipidemia-associated cognitive decline; ameliorates arterial stiffness in a rat model of chronic renal failure.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
In vitro antagonistic properties of a new angiotensin type 1 receptor blocker, azilsartan, in receptor binding and function studies.
Ojima et al.
J.Pharmacol.Exp.Ther., 2011;336:801 -
Inhibition of cognitive decline in mice fed a high-salt and cholesterol diet by the angiotensin receptor blocker, olmes.
Mogi et al.
Neuropharmacology, 2007;53:899 -
Effects of olmes. on arterial stiffness in rats with chronic renal failure.
Chuang et al.
Cardiovasc.Diabetol., 2012;11:66
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citations for Olmesartan
The citations listed below are publications that use Tocris products. Selected citations for Olmesartan include:
2 Citations: Showing 1 - 2
-
A novel luminescence-based-β-arrestin recruitment assay for unmodified receptors.
Authors: Pedersen
J Biol. Chem. 2021;296:100503
-
Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody.
Authors: Robert J Et al.
Cell 2019;176:479-490.e12
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for Olmesartan
There are currently no reviews for this product. Be the first to review Olmesartan and earn rewards!
Have you used Olmesartan?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
