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OB 24 hydrochloride

Catalog #: 6119
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6119/10
6119/50
OB 24 hydrochloride | CAS No. 939825-12-4 | Heme Oxygenase Inhibitors
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Description: Potent and selective heme oxygenase 1 (HO-1) inhibitor

Chemical Name: 1-[[2-[2-(4-Bromophenyl)ethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazole hydrochloride

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

OB 24 hydrochloride is a potent and selective heme oxygenase 1 (HO-1) inhibitor (IC50 values are 1.9 and >100 μM for HO-1 and HO-2 respectively), reduces protein carbonylation and reactive oxygen species formation in advanced prostate cancer cells (PCA). Inhibits cell proliferation in vitro and PCA tumor growth and lymph node/lung metastases in vivo. Synergizes with Taxol (Cat. No. 1097).

Technical Data

M.Wt:
373.67
Formula:
C15H17BrN2O2.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
939825-12-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A novel experimental heme oxygenase-1-targeted therapy for hormone-refractory prostate cancer.
    Alaoui-Jamali et al.
    Cancer Res., 2009;69:8017

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Citations for OB 24 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for OB 24 hydrochloride include:

2 Citations: Showing 1 - 2

  1. Fructose Promotes Cytoprotection in Melanoma Tumors and Resistance to Immunotherapy.
    Authors: Thomas P Et al.
    Cancer Immunol Res  2021;9:227-238
  2. Oxidized Lipoproteins Promote Resistance to Cancer Immunotherapy Independent of Patient Obesity.
    Authors: Carolyn J Et al.
    Cancer Immunol Res  2021;9:214-226

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