NSC 74859
Chemical Name: 2-Hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]benzoic acid
Purity: ≥98%
Biological Activity
NSC 74859 selectively inhibits STAT3 DNA-binding activity in vitro (IC50 values are 86, 160, and >300 μM for STAT3-STAT3, STAT1-STAT3 and STAT1-STAT1 DNA-binding activity respectively). NSC 74859 blocks growth and induces apoptosis preferentially in tumor cells that contain persistently active STAT3 in vitro and arrests tumor growth in a murine xenograft model in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-beta signaling.
Lin et al.
Oncogene, 2009;28:961 -
Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity.
Siddiquee et al.
Proc.Natl.Acad.Sci.U.S.A., 2007;104:7391
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Citations for NSC 74859
The citations listed below are publications that use Tocris products. Selected citations for NSC 74859 include:
2 Citations: Showing 1 - 2
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Local and Systemic STAT3 and p65 NF-KappaB Expression as Progression Markers and Functional Targets for Patients With Cervical Cancer.
Authors: Edmund C Et al.
Front Oncol 2020;10:587132
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The α9 Nicotinic Acetylcholine Receptor Mediates Nicotine-Induced PD-L1 Expression and Regulates Melanoma Cell Proliferation and Migration.
Authors: Yuan-Soon Et al.
Cancers (Basel) 2019;11
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