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NSC 624206

Catalog #: 4993 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4993/10
4993/50
NSC 624206 | CAS No. 13116-77-3 | Ubiquitin-activating Enzyme (E1) Inhibitors
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Description: Ubiquitin-activating enzyme (E1) inhibitor

Chemical Name: N-[2-[[(4-Chlorophenyl)methyl]dithio]ethyl]-1-decanamine hydrochloride

Purity: ≥98%

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Biological Activity

NSC 624206 is an ubiquitin-activating enzyme (E1) inhibitor; prevents tumour suppressor protein p27 ubiquitination in vitro. Blocks the ubiquitin-thioester formation step of the E1 activation reaction, but displays no effect on ubiquitin adenylation.

Technical Data

M.Wt:
410.51
Formula:
C19H32ClNS2.HCl
Solubility:
Soluble to 50 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
13116-77-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Identification and mechanistic studies of a novel ubiquitin E1 inhibitor.
    Ungermannova et al.
    J.Biomol.Screen., 2012;17:421

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