Nogo-66 (1-40)

Biological Activity

Nogo-66 (1-40) is a peptide fragment corresponding to residues 1 - 40 of Nogo-66, the domain of the myelin protein Nogo that inhibits axonal outgrowth. Acts as a competitive antagonist at the Nogo-66 receptor (NgR); blocks Nogo-66- and CNS myelin-induced inhibition of axonal growth, but does not reduce myelin-associated glycoprotein (MAG) inhibition of neurite outgrowth in vitro. Promotes regeneration of hemisected spinal axons and locomotor recovery following spinal injury in vivo.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity.
   Kempf A, Tews B, Arzt M, Weinmann O, Obermair F, Pernet V, Zagrebelsky M, Delekate A, Iobbi C, Zemmar A, Ristic Z, Gullo M, Spies P, Dodd D, Gygax D, Korte M, Schwab M
   PLoS Biol, 2014;12(1):e1001763.
2. Nogo-66 receptor antagonist peptide promotes axonal regeneration.
   GrandPre et al.
   Nature, 2002;417:547
3. Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor.
   Liu et al.
   Science, 2002;297:1190
4. Delayed systemic Nogo-66 receptor antagonist promotes recovery from spinal cord injury.
   Li and Strittmatter
   J.Neurosci., 2003;23:4219

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