Nociceptin

Catalog #: 0910
16 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
0910/1

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Description: Endogenous NOP agonist

Alternative Names: Orphanin FQ

Purity: ≥95%

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Product Details

Citations (16)

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Biological Activity

Nociceptin is an endogenous ligand for the NOP opioid receptor (pK_i = 8.6). Has no significant activity at μ, δ or κ opioid receptors (pK_i < 6).

Technical Data

M.Wt:

1809

Formula:

C₇₉H₁₂₉N₂₇O₂₂

Sequence:

FGGFTGARKSARKLANQ

Solubility:

Soluble to 1 mg/ml in water

Purity:

≥95%

Storage:

Store at -20°C

CAS No:

170713-75-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Structure-activity relationships of nociceptin and related peptides: comparison with dynorphin A.
Guerrini et al.
Peptides, 2000;21:923
The orphan opioid receptor and its endogenous ligand-nociceptin/orphanin FQ.
Henderson and McKnight
TiPS, 1997;18:293
Orphanin FQ: a neuropeptide that activates an opioid like G protein coupled receptor.
Reinscheid et al.
Science, 1995;270:792
Isolation and structure of the endogenous agonist of opioid receptor-like ORL₁ receptor.
Meunier et al.
Nature, 1995;377:532

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Nociceptin

The citations listed below are publications that use Tocris products. Selected citations for Nociceptin include:

16 Citations: Showing 1 - 10

Nociceptin Receptor Is Overexpressed in Non-small Cell Lung Cancer and Predicts Poor Prognosis.
Authors: Wang Et al.
Front Oncol 2019;9:235
Differential Desensitization Observed at Multiple Effectors of Somatic μ-Opioid Receptors Underlies Sustained Agonist-Mediated Inhibition of Proopiomelanocortin Neuron Activity.
Authors: Fox and Hentges
J Neurosci 2017;37:8667
Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics.
Authors: Schmid Et al.
Cell 2017;171:1165
The opioid receptor pharmacology of GSK1521498 compared to other ligands with differential effects on compulsive reward-related behaviours.
Authors: Kelly Et al.
Neurochem Res 2015;232:305
Pharmacological attenuation of chronic alcoholic pancreatitis induced hypersensitivity in rats.
Authors: McIlwrath and Westlund
J Cell Mol Med 2015;21:836
Bupren.-elicited alteration of adenylate cyclase activity in human embryonic kidney 293 cells coexpressing κ-, μ-opioid and nociceptin receptors.
Authors: Wang Et al.
Psychopharmacology (Berl) 2015;19:2587
Modulation of voltage-gated Ca2+ channels by G protein-coupled receptors in celiac-mesenteric ganglion neurons of septic rats.
Authors: Farrag Et al.
BMC Complement Altern Med 2015;10:e0125566
Nociceptin/orphanin FQ decreases glutamate transmission and blocks ethanol-induced effects in the central amygdala of naive and ethanol-dependent rats.
Authors: Kallupi Et al.
Neuropsychopharmacology 2014;39:1081
MinCyc enhances the effectiveness of nociceptin/orphanin FQ during neuropathic pain.
Authors: Popiolek-Barczyk Et al.
Biomed Res Int 2014;2014:762930
Participation of the nociceptin/orphanin FQ receptor in ethanol-mediated locomotor activation and ethanol intake in preweanling rats.
Authors: Miranda-Morales Et al.
Behav Brain Res 2013;245:137

Differential pharmacological actions of meth. and Bupren. in human embryonic kidney 293 cells coexpressing human μ-opioid and opioid receptor-like 1 receptors.
Authors: Lee Et al.
PLoS One 2011;36:2008

S-nitrosothiols modulate G protein-coupled receptor signaling in a reversible and highly receptor-specific manner.
Authors: Kokkola Et al.
BMC Cell Biol 2005;6:21

Evidence in locomotion test for the functional heterogeneity of ORL-1 receptors.
Authors: Kuzmin Et al.
Br J Pharmacol 2004;141:132

Nociceptin inhibits cough in the guinea-pig by activation of ORL(1) receptors.
Authors: McLeod Et al.
World J Gastroenterol 2001;132:1175

Further characterization of the ORL1 receptor-mediated inhibition of noradrenaline release in the mouse brain in vitro.
Authors: Werthwein Et al.
Br J Pharmacol 1999;127:300

Inhibition of tachykinin release from peripheral endings of sensory nerves by nociceptin, a novel opioid peptide.
Authors: Giuliani and Maggi
Br J Pharmacol 1996;118:1567

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