NNC 63-0532
Chemical Name: 8-(1-Naphthalenylmethyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-3-acetic acid, methyl ester
Purity: ≥98%
Biological Activity
NNC 63-0532 is a potent non-peptide agonist for the NOP receptor (EC50 = 305 nM, Ki = 7.3 nM); ~ 12-fold selective over other receptors. Centrally active following systemic administration in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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(8-Naphthalen-1-ylmethyl-4-oxo-1-phenyl-1,3,8-triaza-spiro[4.5]-dec-3-yl)-acetic acid methyl ester (NNC 63-0532) is a novel potent nociceptin receptor agonist.
Thomsen and Hohlweg
Br.J.Pharmacol., 2000;131:903
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Citation for NNC 63-0532
The citations listed below are publications that use Tocris products. Selected citations for NNC 63-0532 include:
1 Citation: Showing 1 - 1
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NOP receptor mediates anti-analgesia induced by agonist-antagonist opioids.
Authors: Gear Et al.
Neuroscience 2014;257:139
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