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NLS-StAx-h

Catalog #: 6531 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6531/100U
NLS-StAx-h
1 Image
Description: Wnt signaling inhibitor; inhibits β-catenin-transcription factor interactions

Purity: ≥95%

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Biological Activity

NLS-StAx-h is a Wnt inhibitor (IC50 = 1.4 μM). Stapled peptide inhibitor of oncogenic Wnt signaling. Inhibits β-catenin-transcription factor interactions. Inhibits proliferation and migration of colorectal cancer cells. Cell permeable.

Technical Data

M.Wt:
3445.26
Formula:
C161H275N55O29
Sequence:
PKKKRKVRRWPRXILDXHVRRVWR

(Modifications: Val-7 = Val-PEG2, Arg-8 = Arg-9 = Arg-12 = Arg-20 = Arg-21 = homo-Arg, X = (S)-2-(4-pentenyl)alanine, X-13 and X-17 stapled together with a double bond, Arg-24 = homo-Arg & C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
2872559-21-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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