(-)-Nicotine ditartrate
Chemical Name: (S)-(-)-1-Methyl-2-(3-pyridyl)pyrrolidine (+)-ditartrate salt
Purity: ≥99%
Biological Activity
(-)-Nicotine ditartrate is a nicotinic acetylcholine receptor (nAChR) agonist (Ki values are 1, > 1000, 4000 and 7130 nM at α4β2, α1β1δγ, rat α7 and human α7 respectively). Exhibits vasoconstrictive, hypertensive and prothrombotic activity in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: A novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I In vitro characterization.
Donnelly-Roberts et al.
J.Pharmacol.Exp.Ther., 1998;285:777 -
Rat α3/β4 subtype of neuronal nicotinic acetylcholine receptor stably expressed in a transfected cell line: Pharmacology of ligand binding and function.
Xiao et al.
Mol.Pharmacol., 1998;54:322 -
Acute infusion of nicotine potentiates NE-induced vasoconstriction in the hamster cheek pouch.
Mayhan
J.Lab.Clin.Med., 1999;133:48
Product Datasheets
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Citations for (-)-Nicotine ditartrate
The citations listed below are publications that use Tocris products. Selected citations for (-)-Nicotine ditartrate include:
12 Citations: Showing 1 - 10
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β2* nicotinic acetylcholine receptor subtypes mediate nicotine-induced enhancement of Pavlovian conditioned responding to an alcohol cue.
Authors: Jean-Marie Et al.
Front Behav Neurosci 2022;16:1004368
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Chronic Lorcaserin Treatment Reverses the Nicotine Withdrawal-Induced Disruptions to Behavior and Maturation in Developing Neurons in the Hippocampus of Rats.
Authors: Marzena Et al.
Int J Mol Sci 2021;22
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A molecular filter for the cnidarian stinging response.
Authors: Lena Et al.
Elife 2020;9
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NACHO Engages N-Glycosylation ER Chaperone Pathways for α7 Nicotinic Receptor Assembly.
Authors: David S Et al.
Cell Rep 2020;32:108025
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Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner.
Authors: Dorst Et al.
Nat Commun 2020;11:5113
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α6-Containing Nicotinic Acetylcholine Receptor Reconstitution Involves Mechanistically Distinct Accessory Components.
Authors: Gu Et al.
Cell Rep 2019;26:866
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Cholinergic Interneurons Amplify Thalamostriatal Excitation of Striatal Indirect Pathway Neurons in Parkinson's Disease Models.
Authors: Asami Et al.
Neuron 2019;101:444-458.e6
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Spontaneous Release Regulates Synaptic Scaling in the Embryonic Spinal Network In Vivo
Authors: Miguel Angel Garcia-Bereguiain Et al.
The Journal of Neuroscience 2016;6:7268
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Identification and in vitro pharmacological characterization of a novel and selective α7 nicotinic acetylcholine receptor agonist, Br-IQ17B.
Authors: Tang Et al.
Iran Biomed J 2015;36:800
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Effect of Transient Inactivation of Ventral Tegmental Area on the Expression and Acquisition of Nicotine-Induced Conditioned Place Preference in Rats.
Authors: Chalabi-Yani Et al.
Elife 2015;19:214
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In vivo comparison of harmine efficacy against psychostimulants: preferential inhibition of the cocaine response through a glutamatergic mechanism.
Authors: Owaisat Et al.
Neurosci Lett 2012;525:12
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OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neurons.
Authors: Leão Et al.
Nat Neurosci 2012;15:1524
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