Neuropeptide FF
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Description: Endogenous NPFF1 and NPFF2 agonist; also MRGPRA agonist
Purity: ≥95%
Biological Activity
Neuropeptide FF is an endogenous antiopioid peptide and agonist at NPFF1 and NPFF2 receptors (Ki values are 2.82 and 0.21 nM respectively). Exhibits anorexigenic effects following i.c.v. administration. Also MRGPRA agonist.Technical Data
M.Wt:
1081.28
Formula:
C54H76N14O10
Sequence:
FLFQPQRF
(Modifications: Phe-8 = C-terminal amide)
Solubility:
Soluble to 0.50 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
99566-27-5
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Central neuropeptide FF reduces feed consumption and affects hypothalamic chemistry in chicks.
Cline et al.
Neuropeptides, 2007;41:433 -
Functional differences between NPFF1 and NPFF2 receptor coupling: high intrinsic activities of RFamide-related peptides on stimulation of[35S]GTPγS binding.
Gouarderes et al.
Neuropharmacology, 2007;52:376 -
Pharmacology and signaling of MAS-related G protein-coupled receptors.
Solinski et al.
Pharmacol.Rev., 2014;66:570
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