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NESS 0327

Catalog #: 5746 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5746/10
5746/50
NESS 0327 | CAS No. 494844-07-4 | Cannabinoid R1/CB1 Antagonists
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Description: Ultra-high affinity and selective CB1 antagonist

Chemical Name: 8-Chloro-1-(2,4-dichlorophenyl)-1,4,5,6-tetrahydro-N-1-piperidinyl-benzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide

Purity: ≥98%

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Biological Activity

NESS 0327 is an ultra-high affinity and selective CB1 receptor antagonist (Ki = 350 fM). Exhibits >60-fold selectivity for CB1 over CB2 receptors. Antagonizes the inhibitory effects of WIN 55,212-2 (Cat. No. 1038) on electrically evoked contractions in mouse isolated vas deferens ex vivo. Also antagonizes the antinociceptive effect of WIN 55,212-2 in tail-flick and hot plate tests in vivo.

Technical Data

M.Wt:
489.82
Formula:
C24H23Cl3N4O
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
494844-07-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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