NBOH-2C-CN hydrochloride
Chemical Name: 4-[2-[[(2-Hydroxyphenyl)methyl]amino]ethyl]-2,5-dimethoxybenzonitrile hydrochloride
Purity: ≥98%
Biological Activity
NBOH-2C-CN hydrochloride is a high affinity, selective 5-HT2A agonist (Ki = 1.3 nM). Exhibits 100-fold selectivity for 5-HT2A over 5-HT2C. Elicits head twitch behavior in mice.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Hallucinogen-like effects of 2-([2-(4-cyano-2,5-dimethoxyphenyl) ethylamino]methyl)phenol (25CN-NBOH), a novel N-benzylphenethylamine with 100-fold selectivity for 5-HT2A receptors, in mice.
Fantegrossi et al.
Psychopharmacology (Berl.), 2014;232:1039 -
Synthesis and structure-activity relationships of N-benzyl phenethylamines as 5-HT2A/2C agonists.
Hansen et al.
ACS.Chem.Neurosci., 2014;5:243
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Citations for NBOH-2C-CN hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for NBOH-2C-CN hydrochloride include:
2 Citations: Showing 1 - 2
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Bimodal modulation of short-term motor memory via dynamic sodium pumps in a vertebrate spinal cord.
Authors: Hongyan Et al.
Curr Biol 2022;32:1038-1048.e2
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Serotonin Receptor 2A Activation Promotes Evolutionarily Relevant Basal Progenitor Proliferation in the Developing Neocortex.
Authors: Wieland B Et al.
Neuron 2020;108:1113-1129.e6
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