NBI 31772
Chemical Name: 1-(3,4-Dihydroxybenzoyl)-6,7-dihydroxy-3-isoquinolinecarboxylic acid
Purity: ≥98%
Biological Activity
NBI 31772 is a high affinity insulin-like growth factor-1 binding protein (IGFBP) inhibitor (Ki values are 1 - 24 nM for all six human subtypes). Displaces insulin-like growth factor-1 (IGF-1) from the IGF-1:IGFBP complex and suppresses IGF1-induced proliferation of 3T3 fibroblasts. Also increases cardiomyocyte proliferation in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Tbx3-dependent amplifying stem cell progeny drives interfollicular epidermal expansion during pregnancy and regeneration
R Ichijo, H Kobayashi, S Yoneda, Y Iizuka, H Kubo, S Matsumura, S Kitano, H Miyachi, T Honda, F Toyoshima
Nat Commun, 2017;8(1):508. -
Discovery of a series of nonpeptide small molecules that inhibit the binding of Ins-like growth factor (IGF) to IGF-binding proteins.
Chen et al.
J.Med.Chem., 2001;44:4001 -
In vivo monitoring of cardiomyocyte proliferation to identify chemical modifiers of heart regeneration.
Choi et al.
Development., 2013;140:660
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Citations for NBI 31772
The citations listed below are publications that use Tocris products. Selected citations for NBI 31772 include:
2 Citations: Showing 1 - 2
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Tbx3-dependent amplifying stem cell progeny drives interfollicular epidermal expansion during pregnancy and regeneration.
Authors: Ichijo Et al.
Nat Commun 2017;8:508
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An O-Glycosylation of Fibronectin Mediates Hepatic Osteodystrophy Through α4β1 Integrin.
Authors: Markus Et al.
J Bone Miner Res 2017;32:70-81
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