NAN-190 hydrobromide
Chemical Name: 1-(2-Methoxyphenyl)-4-(4-phthalimidobutyl)piperazine hydrobromide
Purity: ≥98%
Biological Activity
NAN-190 hydrobromide is a 5-HT1A antagonist.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Effects of the putative 5-HT1A receptor antagonist NAN-190 on free feeding and on feeding induced by the 5-HT1A receptor agonist 8-OH-DPAT in the rat.
Douris
Eur.J.Pharmacol., 1992;219:105 -
Arylpiperazine derivatives as high affinity 5-HT1A serotonin ligands.
Glennon et al.
J.Med.Chem., 1988;31:1968 -
NAN-190: an arylpiperazine analog that antagonizes the stimulus effects of the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT).
Williams and Glennon
Eur.J.Pharmacol., 1988;154:339
Product Datasheets
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Citations for NAN-190 hydrobromide
The citations listed below are publications that use Tocris products. Selected citations for NAN-190 hydrobromide include:
3 Citations: Showing 1 - 3
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Activity-dependent expression of Lmx1b regulates specification of serotonergic neurons modulating swimming behavior.
Authors: Demarque and
Neuron 2010;67:321
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Gαo/i-stimulated proteosomal degradation of RGS20: a mechanism for temporal integration of Gs and Gi pathways.
Authors: Pagano Et al.
Physiol Behav 2008;20:1190
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Involvement of 5-HT1B receptors in collar-induced hypersensitivity to 5-hydroxytryptamine of the rabbit carotid artery.
Authors: Geerts Et al.
Br J Pharmacol 1999;127:1327
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