Nafamostat mesylate
Chemical Name: 4-[(Aminoiminomethyl)amino]benzoic acid 6-(aminoiminomethyl)-2-naphthalenyl ester dimethanesulfonate
Purity: ≥99%
Biological Activity
Nafamostat mesylate is a broad spectrum serine protease inhibitor. Displays selectivity for human tryptase when used at relatively low concentrations. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma. Inhibits SARS-CoV-2 infection in vitro (EC50 = 22.50 μM).Tocris products are for biomedical research use only. They are not intended for human or veterinary use.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Nafamostat mesilate is an extremely potent inhibitor of human tryptase.
Mori et al.
J.Pharmacol.Sci., 2003;92:420 -
A potent tryptase inhibitor nafamostat mesilate dramatically suppressed pulmonary dysfunction induced in rats by a radiographic contrast medium.
Sendo et al.
Br.J.Pharmacol., 2003;138:959 -
Serine protease inhibitors nafamostat mesilate and gabexate mesilate attenuate allergen-induced airway inflammation and eosinophilia in a murine model of asthma.
Chen et al.
J.Allergy Clin.Immunol., 2006;118:105 -
Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro.
Wang et al.
Cell Research, 2020;30:269
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Citation for Nafamostat mesylate
The citations listed below are publications that use Tocris products. Selected citations for Nafamostat mesylate include:
1 Citation: Showing 1 - 1
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Interleukin-33 is activated by allergen- and necrosis-associated proteolytic activities to regulate its alarmin activity during epithelial damage.
Authors: Scott Et al.
Sci Rep 2018;8:3363
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