N-Formyl-Met-Leu-Phe
Purity: ≥95%
Biological Activity
N-Formyl-Met-Leu-Phe is an endogenous chemotactic peptide and agonist for the formyl peptide receptor 1 (FPR1) (Ki = 38 nM). Stimulates aggregation of leukocytes.Technical Data
(Modifications: Met-1 = N-formyl-Met)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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DAMPs Synergize with Cytokines or Fibronectin Fragment on Inducing Chondrolysis but Lose Effect When Acting Alone
L Ding, JA Buckwalter, JA Martin
Mediators Inflamm., 2017;2017(0):2642549. -
Quantitative comparisons of various biological responses of neutrophils to different active and inactive chemotactic factors.
Kreutzer et al.
Immunopharmacology, 1978;1:39 -
Characterization of the binding site on the formyl peptide receptor using three receptor mutants and analogs of Met-Leu-Phe and Met-Met-Trp-Leu-Leu.
Mills et al.
J.Biol.Chem., 2000;275:39012 -
Receptor blockade as a mechanism of deactivation of human neutrophils by pepstatin and formyl-Met-Leu-Phe.
Spilberg et al.
Inflammation, 1984;8:73
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Citations for N-Formyl-Met-Leu-Phe
The citations listed below are publications that use Tocris products. Selected citations for N-Formyl-Met-Leu-Phe include:
2 Citations: Showing 1 - 2
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DAMPs Synergize with Cytokines or Fibronectin Fragment on Inducing Chondrolysis but Lose Effect When Acting Alone.
Authors: Ding Et al.
Mediators Inflamm 2017;2017:2642549
-
Decreased superoxide production in macrophages of long-lived p66Shc knock-out mice.
Authors: Tomilov Et al.
J Biol Chem 2010;285:1153
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