MSOP
Chemical Name: (RS)-α-Methylserine-O-phosphate
Biological Activity
MSOP is a selective group III metabotropic glutamate receptor antagonist. Displays an apparent KD of 51 μM for the L-AP4-sensitive presynaptic mGluR on primary afferent terminals in spinal cord compared to > 700 μM for the (1S,3S)-ACPD-sensitive presynaptic mGlu in the same system. Has no activity on postsynaptic mGlu receptors or on ionotropic glutamate receptors on neonatal rat motoneurons.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Olanzapine: preclinical and clinical profiles of a novel antipsychotic agent.
Tollefson and Taylor
CNS Drug Reviews, 2000;6:303 -
Phosphono substituted amino acids as selective metabotropic glutamate receptor antagonists.
Jane et al.
Phosphorous, Sulphur and Silicon, 1996;109-110:313 -
α-Methyl derivatives of serine-O-phosphate as novel, selective competitive metabotropic glutamate receptor antagonists.
Thomas et al.
Neuropharmacology, 1996;35:637 -
Serine-O-phosphate derivatives as novel, potent and selective metabotropic glutamate receptor (mGluR) antagonists.
Thomas et al.
Soc.Neurosci.Abstr., 1995;21:P616
Product Datasheets
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Citations for MSOP
The citations listed below are publications that use Tocris products. Selected citations for MSOP include:
7 Citations: Showing 1 - 7
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Exposure to Allergen Causes Changes in NTS Neural Activities after Intratracheal Capsaicin Application, in Endocannabinoid Levels and in the Glia Morphology of NTS.
Authors: Spaziano Et al.
Proc Natl Acad Sci U S A 2015;2015:980983
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Long-term potentiation of synaptic transmission in the adult mouse insular cortex: multielectrode array recordings.
Authors: Liu Et al.
J Neurophysiol 2013;110:505
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Enhancement of CA3 hippocampal network activity by activation of group II metabotropic glutamate receptors.
Authors: Ster Et al.
J Neurosci 2011;108:9993
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Vagal afferent control of opioidergic effects in rat brainstem circuits.
Authors: Browning Et al.
Biomed Res Int 2006;575:761
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Vanilloid-mediated heterosynaptic facilitation of inhibitory synaptic input to neurons of the rat dorsal motor nucleus of the vagus.
Authors: Derbenev Et al.
J Physiol 2006;26:9666
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Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on DArgic neurons through a microtubule-dependent mechanism.
Authors: Jiang Et al.
J Neurosci 2006;26:4318
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Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors.
Authors: Melyan Et al.
J Neurosci 2004;24:4530
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