Home / ASK1 Inhibitors / MSC 2032964A

MSC 2032964A

Catalog #: 5641
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5641/50
5641/10
MSC 2032964A | CAS No. 1124381-43-6 | ASK1 Inhibitors
1 Image
Description: Potent and selective ASK1 inhibitor; orally bioavailable

Chemical Name: N-[5-(Cyclopropylamino)-7-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]-3-pyridinecarboxamide

Purity: ≥97%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

MSC 2032964A is a potent and selective ASK1 inhibitor (IC50 = 93 nM). Selective for ASK1 over a panel of 210 kinases. Blocks LPS-induced ASK1 and p38 phosphorylation in cultured mouse astrocytes. Suppresses neuroinflammation in a mouse EAE model. Orally bioavailable and brain penetrant.

Technical Data

M.Wt:
362.31
Formula:
C16H13F3N6O
Solubility:
Soluble to 20 mM in DMSO and to 10 mM in ethanol with gentle warming
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
1124381-43-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for MSC 2032964A

The citations listed below are publications that use Tocris products. Selected citations for MSC 2032964A include:

2 Citations: Showing 1 - 2

  1. IRE1α RIDD activity induced under ER stress drives neuronal death by the degradation of 14-3-3 θ mRNA in cortical neurons during glucose deprivation.
    Authors: Xochitl Et al.
    Cell Death Discov  2021;7:131
  2. IRE1α kinase-mediated unconventional protein secretion rescues misfolded CFTR and pendrin.
    Authors: Ju-Ri Et al.
    Sci Adv  2020;6:eaax9914

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for MSC 2032964A

There are currently no reviews for this product. Be the first to review MSC 2032964A and earn rewards!

Have you used MSC 2032964A?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.