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MSC 1186

Catalog #: 7927 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7927/10
7927/50
MSC 1186 | CAS No. 2871698-23-4 | SRPK3
1 Image
Description: Potent and selective SRPK family inhibitor

Chemical Name: N-[3-[[[2-(6-Chloro-7-fluoro-1H-benzimidazol-2-yl)-4-pyrimidinyl]amino]methyl]-2-pyridinyl]-N-methylmethanesulfonamide

Purity: ≥98%

Product Details
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Biological Activity

MSC1186 is a potent and selective inhibitor of serine arginine protein kinases (SRPK) 3, 1 and 2 (IC50 values are 0.6 nM, 3 nM and 81 nM respectively in biochemical assay; EC50 values in NanoBRETassay are 40 nM, 98 nM and 149 nM, respectively). Shows no activity at CLK and DYRK families (IC50 >10 μM).

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of MSC 1186 is reviewed on the chemical probes website.

Technical Data

M.Wt:
461.9
Formula:
C19H17ClFN7O2S
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2871698-23-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the MSC 1186 probe summary on the SGC website.

Product Datasheets

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