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MS 6105

Catalog #: 8073 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
8073/5
MS 6105 | CAS No. 2891709-58-1 | Active Degraders
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Description: Potent lactate dehydrogenase Degrader (PROTAC®)

Chemical Name: 2-(5-(Cyclopropylmethyl)-3-(3-(6-(13-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-13-oxotridecanamido)hex-1-yn-1-yl)phenyl)-4-(4-sulfamoylbenzyl)-1H-pyrazol-1-yl)thiazole-4-carboxylic acid

Purity: ≥98%

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Biological Activity

MS 6105 is a potent and selective lactate dehydrogenase (LDH) Degrader (PROTAC®; for LDHA and LDHB respectively, DC50 values are 38 nM and 74 nM; Dmax is 93% and 86%). Comprises an LDH inhibitor warhead connected by a linker to a VHL ligand. Suppresses growth of several pancreatic cancer cell lines (IC50 range is 12.2 μM - 16.1 μM). Bioavailable in vivo.

Technical Data

M.Wt:
1228.6
Formula:
C65H81N9O9S3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2891709-58-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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