MS 21570
Chemical Name: N-Methyl-5-[(phenylmethyl)thio]-1,3,4-thiazadiazol-2-amine
Purity: ≥98%
Biological Activity
MS 21570 is a GPR171 antagonist (IC50 = 220 nM). Inhibits BigLEN (Cat.No. 6304) mediated increases in [35S]GTPγS binding in hypothalamic membranes and hyperpolarization of basolateral amygdala pyramidal neurons. Reduces anxiety-like behavior and fear conditioning in mice.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
The BigLEN-GPR171 peptide receptor system within the basolateral amygdala regulates anxiety-like behavior and contextual fear conditioning.
Bobeck et al.
Neuropsychopharmacology, 2017;42:2527
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citation for MS 21570
The citations listed below are publications that use Tocris products. Selected citations for MS 21570 include:
1 Citation: Showing 1 - 1
-
The GPR171 pathway suppresses T cell activation and limits antitumor immunity.
Authors: Richard D Et al.
Nat Commun 2021;12:5857
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for MS 21570
There are currently no reviews for this product. Be the first to review MS 21570 and earn rewards!
Have you used MS 21570?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
