Mpro 13b-K
Chemical Name: tert-Butyl (1-((S)-1-(((S)-4-(benzylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)amino)-3-cyclopropyl-1-oxopropan-2-yl)-2-oxo-1,2-dihydropyridin-3-yl)carbamate
Purity: ≥97%
Biological Activity
Mpro 13b-K is a coronavirus Mpro inhibitor (IC50 values are 0.12, 0.58 and 0.9 μM for recombinant Mpro from SARS-CoV-2, MERS-CoV and SARS-CoV, respectively). Mpro 13b-K inhibits SARS-CoV-2 infection of human Calu3 cells (IC50 = 2.4 μM). The compound also inhibits SARS-CoV-2 replication in A549-ACE2-TMPRSS2, VeroE6 and Huh7 cell cultures (EC50 values are 0.84, 1.3 and 3.4 μM). Exhibits oral and inhalative bioavailability.Please note that this product was previously known as Mpro 13b.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors.
Zhang et al.
Science., 2020;368:409
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