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Mouse OSMR beta Antibody

Catalog #: AF662
15 Citations Datasheet / COA / SDS
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AF662
AF662-SP
Product Details
Citations (15)
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Mouse OSMR beta Antibody Summary

Species Reactivity
Mouse
Specificity
Detects mouse OSM R beta in direct ELISAs and Western blots.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse OSM R beta
Glu24-Leu738
Accession # O70458
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Western Blot
0.1 µg/mL
Recombinant Mouse OSM R beta Fc Chimera (Catalog # 662-OR)
Immunohistochemistry
5-15 µg/mL
Immersion fixed frozen sections of mouse embryo (E13.5-15.5)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: OSMR beta

Oncostatin M (OSM) is a member of the IL-6 family of cytokines that share the gp130 as a common signal transducing receptor subunit. Human OSM signals through two types of human OSM receptor complexes: the type I complex comprising the leukemia inhibitory factor receptor beta (LIF R beta ) and gp130, the type II complex made up of OSM receptor beta (OSM R beta ) and gp130. In contrast, mouse OSM signals only through the mouse OSM R beta and gp130 complex. Mouse OSM R beta cDNA encodes a 971 amino acid (aa) residue type I transmembrane protein which contains a 23 aa residue signal peptide, an extracellular domain of 714 aa, a transmembrane domain of 20 aa and a 214 aa cytoplasmic domain. Mouse OSM R beta alone binds mOSM with low-affinity, but forms a high-affinity binding complex in the presence of gp130. Mouse OSM R beta is 55% identical at the amino acid sequence level to human OSM R beta.

References
  1. Lindberg, R.A. et al. (1998) Mol. Cell. Biol. 18:3357.
  2. Tanaka, M. et al. (1999) Blood 93:804.
Long Name
Oncostatin M Receptor beta
Entrez Gene IDs
9180 (Human); 18414 (Mouse); 310132 (Rat)
Alternate Names
IL-31 receptor subunit beta; IL-31R subunit beta; IL-31RB; IL-31R-beta; Interleukin-31 receptor subunit beta; MGC150627; MGC75127; oncostatin M receptor; oncostatin-M specific receptor beta subunit; oncostatin-M-specific receptor subunit beta; OSM R beta; OSMR beta; OSMR; OSMRB; OSMRBMGC150626; PLCA1

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Citations for Mouse OSMR beta Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

15 Citations: Showing 1 - 10
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  1. Adipose Tissue Dysfunction Occurs Independently of Obesity in Adipocyte‐Specific Oncostatin Receptor Knockout Mice
    Authors: Jacqueline M. Stephens, Jennifer L. Bailey, Hardy Hang, Victoria Rittell, Marilyn A. Dietrich, Randall L. Mynatt et al.
    Obesity (Silver Spring)
  2. EDA2R-NIK signalling promotes muscle atrophy linked to cancer cachexia
    Authors: Bilgic, SN;Domaniku, A;Toledo, B;Agca, S;Weber, BZC;Arabaci, DH;Ozornek, Z;Lause, P;Thissen, JP;Loumaye, A;Kir, S;
    Nature
    Species: Transgenic Mouse, Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  3. Essential roles of the cytokine oncostatin M in crosstalk between muscle fibers and immune cells in skeletal muscle after aerobic exercise
    Authors: T Komori, Y Morikawa
    The Journal of Biological Chemistry, 2022-11-09;0(0):102686.
    Species: Mouse
    Sample Types: Tissue Homogenates, Whole Tissue
    Applications: IHC, Western Blot
  4. Concomitant Activation of OSM and LIF Receptor by a Dual-Specific hlOSM Variant Confers Cardioprotection after Myocardial Infarction in Mice
    Authors: H Lörchner, JM Adrian-Seg, C Waechter, R Wagner, ME Góes, N Brachmann, K Sreenivasa, A Wietelmann, S Günther, N Doll, T Braun, J Pöling
    International Journal of Molecular Sciences, 2021-12-29;23(1):.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  5. Repression of Osmr and Fgfr1 by miR-1/133a prevents cardiomyocyte dedifferentiation and cell cycle entry in the adult heart
    Authors: M Valussi, J Besser, K Wystub-Lis, S Zukunft, M Richter, T Kubin, T Boettger, T Braun
    Science Advances, 2021-10-13;7(42):eabi6648.
    Species: Mouse, Rat, Transgenic Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  6. Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis
    Authors: J Martínez-F, A Prescott, S van Kaster, DL Pedrioli, I McLean, A Moles, T Reinheckel, V Poli, C Watts
    Nat Commun, 2018-12-17;9(1):5343.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  7. Loss of oncostatin M signaling in adipocytes induces insulin resistance and adipose tissue inflammation in vivo
    Authors: Carrie M Elks
    J Biol Chem, 2016-06-20;0(0):.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  8. Oncostatin M regulates SOCS3 mRNA stability via the MEK-ERK1/2-pathway independent of p38(MAPK)/MK2.
    Authors: Ehlting C, Bohmer O, Hahnel M, Thomas M, Zanger U, Gaestel M, Knoefel W, Schulte Am Esch J, Haussinger D, Bode J
    Cell Signal, 2015-01-03;27(3):555-67.
    Species: Mouse
    Sample Types: Protein
    Applications: Western Blot
  9. Oncostatin m, an inflammatory cytokine produced by macrophages, supports intramembranous bone healing in a mouse model of tibia injury.
    Authors: Guihard P, Boutet M, Brounais-Le Royer B, Gamblin A, Amiaud J, Renaud A, Berreur M, Redini F, Heymann D, Layrolle P, Blanchard F
    Am J Pathol, 2015-01-02;185(3):765-75.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  10. Oncostatin M acting via OSMR, augments the actions of IL-1 and TNF in synovial fibroblasts.
    Authors: Le Goff B, Singbrant S, Tonkin B, Martin T, Romas E, Sims N, Walsh N
    Cytokine, 2014-04-22;68(2):101-9.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  11. Deficiency of oncostatin M receptor beta (OSMRbeta) exacerbates high-fat diet-induced obesity and related metabolic disorders in mice.
    Authors: Komori T, Tanaka M, Senba E, Miyajima A, Morikawa Y
    J Biol Chem, 2014-04-02;289(20):13821-37.
    Species: Mouse
    Sample Types: Tissue Homogenates, Whole Cells
    Applications: Flow Cytometry, Western Blot
  12. Lack of oncostatin M receptor beta leads to adipose tissue inflammation and insulin resistance by switching macrophage phenotype.
    Authors: Komori T, Tanaka M, Senba E, Miyajima A, Morikawa Y
    J Biol Chem, 2013-06-11;288(30):21861-75.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  13. A unique loop structure in oncostatin M determines binding affinity toward oncostatin M receptor and leukemia inhibitory factor receptor.
    Authors: Chollangi, Srinivas, Mather, Timothy, Rodgers, Karla K, Ash, John D
    J Biol Chem, 2012-07-24;287(39):32848-59.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: ELISA Development
  14. Microarray and Proteomic Analysis of Breast Cancer Cell and Osteoblast Co-cultures: ROLE OF OSTEOBLAST MATRIX METALLOPROTEINASE (MMP)-13 IN BONE METASTASIS.
    Authors: Morrison C, Mancini S, Cipollone J, Kappelhoff R, Roskelley C, Overall C
    J. Biol. Chem., 2011-07-22;286(39):34271-85.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  15. Oncostatin M promotes excitotoxicity by inhibiting glutamate uptake in astrocytes: implications in HIV-associated neurotoxicity
    Authors: Shamsudheen Moidunny, Marco Matos, Evelyn Wesseling, Santanu Banerjee, David J. Volsky, Rodrigo A. Cunha et al.
    Journal of Neuroinflammation

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