Mouse Coagulation Factor II (NP_034298.1) VersaClone cDNA
Mouse Coagulation Factor II (NP_034298.1) VersaClone cDNA Summary
Specifications
Product Datasheets
Background: Coagulation Factor II/Thrombin
Coagulation Factor II/thrombin is an essential component of the coagulation cascade in which it converts fibrinogen to fibrin, activates coagulation factors V, VII, VIII, XIII and forms complexes with protein C and thrombomodulin. It also activates platelets and regulates the behavior of additional cells through protease-activated receptors (PARs). A plasma serine protease, thrombin is synthesized as a 622 amino acid precursor with a 24 amino acid signal peptide and a 19 residue pro peptide. The mature chain can be further processed into several forms including those designated as alpha-, beta- and gamma-thrombin.
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