Mouse CCR2 Alexa Fluor® 700-conjugated Antibody Summary
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of CCR2 in Mouse Splenocytes by Flow Cytometry. Mouse splenocytes were stained with Rat Anti-Mouse CCR2 Alexa Fluor® 700-conjugated Monoclonal Antibody (Catalog # FAB5538N) and Rat Anti-Mouse Gr-1/Ly-6G Fluorescein-conjugated Monoclonal Antibody (Catalog # FAB1037F). Quadrant markers were set based on control antibody staining (Catalog # IC013N). View our protocol for Staining Membrane-associated Proteins.
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Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: CCR2
CCR2, also known as CD192, is a 38 kDa 7TM chemokine receptor that preferentially binds CCL2, CCL7, and CCL13. CCR2 is expressed by multiple hematopoietic cells, endothelial cells, fibroblasts, neurons, and smooth muscle cells. It functions as an HIV fusion co-factor and facilitates T cell recruitment during inflammation. Two alternate splice forms (CCR2A and CCR2B) differ only by the addition of 14 amino acids to the intracellular carboxyl terminal. Mouse CCR2 shares 67% and 95% aa sequence identity with human and rat CCR2, respectively.
Product Datasheets
Product Specific Notices
This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.
Citations for Mouse CCR2 Alexa Fluor® 700-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
12
Citations: Showing 1 - 10
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Dipeptidase-1 governs renal inflammation during ischemia reperfusion injury
Authors: A Lau, JJ Rahn, M Chappellaz, H Chung, H Benediktss, D Bihan, A von Mässen, A Linkermann, CN Jenne, SM Robbins, DL Senger, IA Lewis, J Chun, DA Muruve
Science Advances, 2022-02-02;8(5):eabm0142.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
The CD200 Regulates Inflammation in Mice Independently of TNF-&alpha Production
Authors: K Tonecka, A Braniewska, Z Pilch, Z Sas, M Skorzynski, E Manuali, TP Rygiel
International Journal of Molecular Sciences, 2021-05-19;22(10):.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination
Authors: J Yu, MD Green, S Li, Y Sun, SN Journey, JE Choi, SM Rizvi, A Qin, JJ Waninger, X Lang, Z Chopra, I El Naqa, J Zhou, Y Bian, L Jiang, A Tezel, J Skvarce, RK Achar, M Sitto, BS Rosen, F Su, SP Narayanan, X Cao, S Wei, W Szeliga, L Vatan, C Mayo, MA Morgan, CA Schonewolf, K Cuneo, I Kryczek, VT Ma, CD Lao, TS Lawrence, N Ramnath, F Wen, AM Chinnaiyan, M Cieslik, A Alva, W Zou
Nature Medicine, 2021-01-04;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Targeting Lymph Node Niches Enhances Type 1 Immune Responses to Immunization
Authors: J Lian, AJ Ozga, CL Sokol, AD Luster
Cell Rep, 2020-05-26;31(8):107679.
Species: Mouse
Sample Types:
Applications: IHC -
Sex-specific adipose tissue imprinting of regulatory T cells
Authors: A Vasanthaku, D Chisanga, J Blume, R Gloury, K Britt, DC Henstridge, Y Zhan, SV Torres, S Liene, N Collins, E Cao, T Sidwell, C Li, RG Spallanzan, Y Liao, PA Beavis, T Gebhardt, N Trevaskis, SL Nutt, JD Zajac, RA Davey, MA Febbraio, D Mathis, W Shi, A Kallies
Nature, 2020-02-26;0(0):.
Species: Mouse
Sample Types: Cells
Applications: Flow Cytometry -
Loss of IL-10 Promotes Differentiation of Microglia to a M1 Phenotype
Authors: B Laffer, D Bauer, S Wasmuth, M Busch, TV Jalilvand, S Thanos, G Meyer Zu H, K Loser, T Langmann, A Heiligenha, M Kasper
Front Cell Neurosci, 2019-10-09;13(0):430.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Robust Control of a Brain-Persisting Parasite through MHC I Presentation by Infected Neurons
Authors: A Salvioni, M Belloy, A Lebourg, E Bassot, V Cantaloube, V Vasseur, S Blanié, RS Liblau, E Suberbiell, EA Robey, N Blanchard
Cell Rep, 2019-06-11;27(11):3254-3268.e8.
Species: Transgenic Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Dectin-2-induced CCL2 production in tissue-resident macrophages ignites cardiac arteritis
Authors: C Miyabe, Y Miyabe, L Moreno, J Lian, RA Rahimi, NN Miura, N Ohno, Y Iwakura, T Kawakami, AD Luster
J. Clin. Invest., 2019-06-06;130(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
HIF-1? is a key regulator in potentiating suppressor activity and limiting the microbicidal capacity of MDSC-like cells during visceral leishmaniasis
Authors: A Hammami, BM Abidin, T Charpentie, A Fabié, AP Duguay, KM Heinonen, S Stäger
PLoS Pathog., 2017-09-11;13(9):e1006616.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Infection-adapted emergency hematopoiesis promotes visceral leishmaniasis
Authors: BM Abidin, A Hammami, S Stäger, KM Heinonen
PLoS Pathog., 2017-08-07;13(8):e1006422.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Leishmania promastigotes induce cytokine secretion in macrophages through the degradation of synaptotagmin XI.
Authors: Arango Duque G, Fukuda M, Turco S, Stager S, Descoteaux A
J Immunol, 2014-07-25;193(5):2363-72.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Role of MR1-driven signals and amphiregulin on the recruitment and repair function of MAIT cells during skin wound healing
Authors: Anastasia du Halgouet, Aurélie Darbois, Mansour Alkobtawi, Martin Mestdagh, Aurélia Alphonse, Virginie Premel et al.
Immunity
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