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MOMBA

Catalog #: 7926 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7926/250
MOMBA | CAS No. 6880-04-2 | DREADD Activators
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Description: Selective orthostatic agonist of hFFA2-DREADDs

Chemical Name: 4-Methoxy-3-methylbenzoic acid

Purity: ≥98%

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Biological Activity

MOMBA is a selective orthosteric agonist for human free fatty acid 2 (hFFA2) engineered receptors, designer receptors activated by designer drugs (DREADD), it shows no activity to wild-type hFFA2, hFFA3, and mouse FFA2. MOMBA inhibit forskolin-stimulated cAMP levels in cells expressing the hFFA2-DREADD receptor with improved potency and equivalent efficacy to Sorbic acid (Cat. No. 7119). In hFFA2-DREADD transgenic mice, MOMBA treatment significantly reduces gut transit and promotes concentration-dependent release of GLP-1 from colonic crypts. Orally bioavailable.

Technical Data

M.Wt:
166.17
Formula:
C9H10O3
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
6880-04-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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