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MM 54

Catalog #: 5992 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5992/1
MM 54
1 Image
Description: Potent apelin antagonist

Purity: ≥95%

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Biological Activity

MM 54 is a potent apelin receptor antagonist (Ki = 82 nM; IC50 = 93 nM). Antagonizes the inhibitory affect of [Pyr1]-Apelin-13 on forskolin-induced cAMP accumulation in CHO-K1-APJ cells. Recuces tumor expansion and lengthens survival time in a mouse xenograft model of glioblastoma.

Technical Data

M.Wt:
1737.15
Formula:
C70H121N29O15S4
Sequence:
CRPRLCKHCRPRLC

(Modifications: Disulfide bridges: 1-6, 9-14)

Solubility:
Soluble to 2 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
1313027-43-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Discovery of a competitive apelin receptor (APJ) antagonist.
    Macaluso et al.
    ChemMedChem, 2011;6:1017
  2. Pharmacological targeting of apelin impairs glioblastoma growth.
    Harford-Wright et al.
    Brain, 2017;140:2939

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