ML 347
Chemical Name: 5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline
Purity: ≥98%
Biological Activity
ML 347 is a potent and selective ALK2 and ALK1 inhibitor (IC50 values are 32 and 46 nM, respectively); displays >200 fold selectivity over ALK3 and ALK6 and >400 fold selectivity over VEGF2. Exhibits no activity at ALK4, ALK5 or in a panel of related kinases. Inhibits BMP4 signaling in a functional assay (IC50 = 152 nM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN
Engers et al.
Bioorg Med Chem Lett., 2013;23:3248
Product Datasheets
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Citations for ML 347
The citations listed below are publications that use Tocris products. Selected citations for ML 347 include:
2 Citations: Showing 1 - 2
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Reciprocal SOX2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer.
Authors: Kathleen Et al.
Cell Rep 2022;40:111066
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Epigenetic Regulation of GDF2 Suppresses Anoikis in Ovarian and Breast Epithelia.
Authors: Varadaraj Et al.
Neoplasia 2015;17:826
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