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ML 339

Catalog #: 5943 Datasheet / COA / SDS
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5943/10
5943/50
ML 339 | CAS No. 2080300-49-6 | Chemokine Receptor Antagonists
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Description: Potent and selective hCXCR6 antagonist

Chemical Name: N-[(1R,3S,5S)-9-(2-((2-Chlorophenyl)amino)-2-exoethyl)-9-azabicyclo[3.3.1]nonan-3-yl)-3,4,5-trimethoxybenzamide

Purity: ≥98%

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Biological Activity

ML 339 is a potent and selective hCXCR6 antagonist (IC50 = 140 nM); 100-fold less active at the murine CXCR6 receptor (IC50 = 18 μM). Exhibits selectivity over CXCR5, CXCR4, CCR6 and APJ receptors (IC50 >79 μM).

Technical Data

M.Wt:
502
Formula:
C26H32ClN3O5
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
2080300-49-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Probing the CXCR6/CXCL16 Axis: targeting prevention of prostate cancer metastasis.
    Hershberger et al.
    Probe Reports from the NIH Molecular Libraries Program, 2012;

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