ML 193

Catalog # Availability Size / Price Qty
4860/10
ML 193 | CAS No. 713121-80-3 | GPR55 Receptor Antagonists
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Description: Potent, selective GPR55 antagonist
Alternative Names: CID 1261822

Chemical Name: N-[4-[[(3,4-Dimethyl-5-isoxazolyl)amino]sulfonyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide

Purity: ≥98%

Product Details
Citations (3)
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Biological Activity

ML 193 is a selective GPR55 antagonist (IC50 = 221 nM). Exhibits >27-, >145- and >145-fold selectivity for GPR55 over CB1, GPR35 and CB2, respectively. Inhibits ERK signaling in vitro.

Technical Data

M.Wt:
527.59
Formula:
C28H25N5O4S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
713121-80-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Screening for selective ligands for GPR55 - antagonists.
    Heynen-Genel et al.
    Probe Reports from the NIH Molecular Libraries Program, 2010;
  2. Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands.
    Kotsikorou et al.
    Biochemistry, 2013;52:9456

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Citations for ML 193

The citations listed below are publications that use Tocris products. Selected citations for ML 193 include:

3 Citations: Showing 1 - 3

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