ML 193
Chemical Name: N-[4-[[(3,4-Dimethyl-5-isoxazolyl)amino]sulfonyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide
Purity: ≥98%
Biological Activity
ML 193 is a selective GPR55 antagonist (IC50 = 221 nM). Exhibits >27-, >145- and >145-fold selectivity for GPR55 over CB1, GPR35 and CB2, respectively. Inhibits ERK signaling in vitro.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Screening for selective ligands for GPR55 - antagonists.
Heynen-Genel et al.
Probe Reports from the NIH Molecular Libraries Program, 2010; -
Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands.
Kotsikorou et al.
Biochemistry, 2013;52:9456
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citations for ML 193
The citations listed below are publications that use Tocris products. Selected citations for ML 193 include:
3 Citations: Showing 1 - 3
-
Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells.
Authors: Alharris Et al.
Oncotarget 2019;10:45
-
Anti-neuroinflammatory effects of GPR55 antagonists in LPS-activated primary microglial cells.
Authors: Saliba Et al.
J Neuroinflammation 2018;15:322
-
Lysophosphatidylcholine elicits intracellular calcium signaling in GPR55-dependent manner.
Authors: Drzazga
Biochem Biophys Res Commun 2017;489(2):243
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for ML 193
There are currently no reviews for this product. Be the first to review ML 193 and earn rewards!
Have you used ML 193?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image