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ML 141

Catalog #: 4266
23 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4266/10
4266/50
ML 141 | CAS No. 71203-35-5 | Rho GTPase Inhibitors
1 Image
Description: Selective Cdc42 Rho family inhibitor
Alternative Names: CID 2950007

Chemical Name: 4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]benzenesulfonamide

Purity: ≥99%

Product Details
Citations (23)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

ML 141 is an allosteric inhibitor of Cdc42 GTPase (EC50 = 2.1 μM). Selective for Cdc42 over other members of the Rho GTPase family including Rac1, Rab2 and Rab7. Inhibits ovarian cancer cell migration in vitro.

Technical Data

M.Wt:
407.49
Formula:
C22H21N3O3S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
71203-35-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Identification of DKK-1 as a novel mediator of statin effects in human endothelial cells
    M Pontremoli, M Brioschi, R Baetta, S Ghilardi, C Banfi
    Sci Rep, 2018;8(1):16671.
  2. Endophilin marks and controls a clathrin-independent endocytic pathway.
    Boucrot E, Ferreira A, Almeida-Souza L, Debard S, Vallis Y, Howard G, Bertot L, Sauvonnet N, McMahon H
    Nature, 2015;517(7535):460-5.
  3. Inter-cellular exchange of cellular components via VE-cadherin-dependent trans-endocytosis.
    Sakurai T, Woolls M, Jin S, Murakami M, Simons M
    PLoS ONE, 2014;9(6):e90736.
  4. Enhanced sphingosine-1-phosphate receptor 2 expression underlies female CNS autoimmunity susceptibility.
    Cruz-Orengo L, Daniels B, Dorsey D, Basak S, Grajales-Reyes J, McCandless E, Piccio L, Schmidt R, Cross A, Crosby S, Klein R
    J Clin Invest, 2014;124(6):2571-84.
  5. Characterization of a Cdc42 GTPase Inhibitor and its Use as a Molecular Probe.
    Hong et al.
    J.Biol.Chem., 2013;:Epub
  6. A potent and selective inhibitor of Cdc42 GTPase.
    Surviladze et al.
    Probe Reports from the Molecular Libraries Program, 2010;:NBK5196
  7. Concerted regulation of actin polymerization during constitutive secretion by Cortactin and PKD2
    F Weeber, A Becher, T Seibold, T Seufferlei, T Eiseler
    J. Cell. Sci., 2019;0(0):.

Product Datasheets

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Citations for ML 141

The citations listed below are publications that use Tocris products. Selected citations for ML 141 include:

23 Citations: Showing 1 - 10

  1. Local changes in microtubule network mobility instruct neuronal polarization and axon specification.
    Authors: Klara I Et al.
    Sci Adv  2022;8:eabo2343
  2. Identification of a pharmacological approach to reduce ACE2 expression and development of an in vitro COVID-19 viral entry model.
    Authors: Raymond P Et al.
    J Virus Erad  2022;8:100307
  3. The Process of Filopodia Induction during HPV Infection.
    Authors: Patricio I Et al.
    Viruses  2022;14
  4. Caveolae couple mechanical stress to integrin recycling and activation.
    Authors: Sara Et al.
    Elife  2022;11
  5. Statin-mediated disruption of Rho GTPase prenylation and activity inhibits respiratory syncytial virus infection.
    Authors: Wenming Et al.
    Commun Biol  2021;4:1239
  6. FBP17-mediated finger-like membrane protrusions in cell competition between normal and RasV12-transformed cells.
    Authors: Shiro Et al.
    iScience  2021;24:102994
  7. Zc3h10 regulates adipogenesis by controlling translation and F-actin/mitochondria interaction.
    Authors: Donatella Et al.
    J Cell Biol  2021;220
  8. Wnt5a modulates dendritic spine dynamics through the regulation of Cofilin via small Rho GTPase activity in hippocampal neurons.
    Authors: Nibaldo C Et al.
    J Neurochem  2021;158:673-693
  9. A Non-canonical Pathway with Potential for Safer Modulation of Transforming Growth Factor-β1 in Steroid-Resistant Airway Diseases.
    Authors: Li Et al.
    iScience  2019;12:232
  10. Mechanochemical feedback control of dynamin independent endocytosis modulates membrane tension in adherent cells.
    Authors: Thottacherry Et al.
    Nat Commun  2018;9:4217
  11. Identification of DKK-1 as a novel mediator of statin effects in human endothelial cells.
    Authors: Pontremoli Et al.
    Sci Rep  2018;8:16671
  12. Cdc42 controls primary mesenchyme cell morphogenesis in the sea urchin embryo.
    Authors: Sepúlveda-Ramírez Et al.
    Dev Biol  2018;437:140
  13. FBP17 and CIP4 recruit SHIP2 and lamellipodin to prime the plasma membrane for fast endophilin-mediated endocytosis.
    Authors: Hak Et al.
    Nat Cell Biol  2018;20:1023
  14. Chlamydia exploits filopodial capture and a macropinocytosis-like pathway for host cell entry.
    Authors: Ford Et al.
    PLoS Pathog  2018;14:e1007051
  15. GOLPH3 drives cell migration by promoting Golgi reorientation and directional trafficking to the leading edge.
    Authors: Xing Et al.
    Mol Biol Cell  2016;27:3828
  16. Human metapneumovirus Induces Reorganization of the Actin Cytoskeleton for Direct Cell-to-Cell Spread.
    Authors: Najjar Et al.
    PLoS Pathog  2016;12:e1005922
  17. Dynasore disrupts trafficking of herpes simplex virus proteins.
    Authors: Mues Et al.
    J Virol  2015;89:6673
  18. Rho GTPases and the downstream effectors actin-related protein 2/3 (Arp2/3) complex and myosin II induce membrane fusion at self-contacts.
    Authors: Sumida and Yamada
    J Biol Chem  2015;290:3238
  19. Competition for actin between two distinct F-actin networks defines a bistable switch for cell polarization.
    Authors: Lomakin Et al.
    Nat Cell Biol  2015;17:1435
  20. P2Y2 nucleotide receptor activation enhances the aggregation and self-organization of dispersed salivary epithelial cells.
    Authors: El-Sayed Et al.
    Nat Commun  2014;307:C83
  21. Transforming growth factor β-induced superficial zone protein accumulation in the surface zone of articular cartilage is dependent on the cytoskeleton.
    Authors: McNary Et al.
    Tissue Eng Part A  2014;20:921
  22. Rac1 and Cdc42 GTPases regulate shear stress-driven β-catenin signaling in osteoblasts.
    Authors: Wan Et al.
    Biochem Biophys Res Commun  2013;433:502
  23. Magnetic nanoparticle-mediated massively parallel mechanical modulation of single-cell behavior.
    Authors: Tseng Et al.
    Am J Physiol Cell Physiol  2012;9:1113

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