MKT 077

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function.
   Wadhwa et al.
   Cancer Res., 2000;60:6818
2. Rhodacyanine dye MKT-077 inhibits in vitro telomerase activity but has no detectable effects on telomerase activity in vivo.
   Wadhwa et al.
   Cancer Res., 2002;62:4434
3. Treatment of Ras-induced cancers by the F-actin cappers tensin and chaetoglobosin K, in combination with the caspase-1 inhibitor N1445.
   Tikoo et al.
   Cancer J.Sci.Am., 1999;5:293
4. Pharmacological targeting of the Hsp70 chaperone.
   Patury et al.
   Curr.Top.Med.Chem., 2009;9:1337

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