Home / Nicotinic Acid Receptor (GPR109) Agonists / MK 1903

MK 1903

Catalog #: 4622
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4622/10
MK 1903 | CAS No. 1268882-43-4 | Nicotinic Acid Receptor (GPR109) Agonists
1 Image
Description: Potent and selective GPR109A (HCA2) agonist

Chemical Name: (4aR,5aR)-4,4a,5,5a-Tetrahydro-1H-cyclopropa[4,5]cyclopenta[1,2]pyrazole-3-carboxylic acid

Purity: ≥98%

Product Details
Citations (4)
Supplemental Products
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

MK 1903 is a potent and selective hydroxycarboxylic acid receptor 2 (HCA2, GPR109A) full agonist; exhibits greater potency than niacin in a whole cell HTRF-cAMP assay (EC50 values are 12.9 and 51 nM respectively). Exhibits no binding at the GRP109B receptor.

Technical Data

M.Wt:
164.16
Formula:
C8H8N2O2
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1268882-43-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for MK 1903

The citations listed below are publications that use Tocris products. Selected citations for MK 1903 include:

4 Citations: Showing 1 - 4

  1. Targeting gut dysbiosis against inflammation and impaired autophagy in Duchenne muscular dystrophy.
    Authors: Elisabetta Et al.
    EMBO Mol Med  2023;15:e16225
  2. Potential role of the hydroxyl carboxylic acid receptor type 2 (HCAR2) in microglia pathophysiology: A possible cross-talk with C-X-C chemokine receptor 1 (CXCR1)
    Authors: Perrone Et al.
    Neuropharmacology  2023;
  3. Identification of the novel role of butyrate as AhR ligand in human intestinal epithelial cells
    Authors: Marinelli Et al.
    Sci.Rep.  2019;9:643
  4. Butyrate Produced by Commensal Bacteria Down-Regulates Indolamine 2,3-Dioxygenase 1 (IDO-1) Expression via a Dual Mechanism in Human Intestinal Epithelial Cells.
    Authors: Martin-Gallausiaux Et al.
    Front Immunol  2019;9:2838

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs
Loading...

Reviews for MK 1903

There are currently no reviews for this product. Be the first to review MK 1903 and earn rewards!

Have you used MK 1903?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.