Metastin (human)
Purity: ≥95%
Biological Activity
Metastin (human) is a potent endogenous ligand of the kisspeptin receptor (KISS1, GPR54). Binds with high affinity to rat and human KISS1 receptors with Ki values of 1.80 and 1.45 nM respectively. Inhibits chemotaxis, invasion and metastasis of human melanomas and breast carcinomas. Stimulates gonadotropin secretion following i.c.v. administration.Technical Data
(Modifications: Phe-54 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54.
Kotani et al.
J.Biol.Chem., 2001;276:34631 -
Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor.
Ohtaki et al.
Nature, 2001;411:613 -
A role for kisspeptins in the regulation of g.tropin secretion in the mouse.
Gottsch et al.
Endocrinology, 2004;145:4073
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Citation for Metastin (human)
The citations listed below are publications that use Tocris products. Selected citations for Metastin (human) include:
1 Citation: Showing 1 - 1
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The pregnant mouse uterus exhibits a functional kisspeptin/KISS1R signaling system on the day of embryo implantation.
Authors: Fayazi Et al.
Nat Chem Biol 2015;13:105
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