Home / 5-HT2A Receptor Antagonists / MDL 11,939

MDL 11,939

Catalog #: 0870
8 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
0870/10
0870/50
MDL 11,939 | CAS No. 107703-78-6 | 5-HT2A Receptor Antagonists
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Description: 5-HT2A antagonist

Chemical Name: α-Phenyl-1-(2-phenylethyl)-4-piperidinemethanol

Purity: ≥99%

Product Details
Citations (8)
Supplemental Products
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

MDL 11,939 is an orally active 5-HT2A receptor antagonist; displays selectivity for 5-HT2A receptors over 5-HT2C receptors (Ki values are 0.54, 2.5, 81.6 and ~10,000 nM at rabbit 5-HT2A, human 5-HT2A, rabbit 5-HT2C and human 5-HT2C receptors respectively).

Technical Data

M.Wt:
295.42
Formula:
C20H25NO
Solubility:
Soluble to 50 mM in ethanol and to 50 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
107703-78-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  2. Antagonist binding at 5-HT2A and 5-HT2C receptors in the rabbit: high correlation with the profile for the human receptors.
    Aloyo and Harvey
    Eur.J.Pharmacol., 2000;406:163
  3. Pharmacological effects of MDL 11,939: a selective, centrally acting antagonist of 5-HT2 receptors.
    Dudley et al.
    Drug Dev.Res., 1988;13:29
  4. Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-dazepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive
    Jensen et al.
    J.Med.Chem., 2013;56:1211

Product Datasheets

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Citations for MDL 11,939

The citations listed below are publications that use Tocris products. Selected citations for MDL 11,939 include:

8 Citations: Showing 1 - 8

  1. Blockade of multiple monoamines receptors reduce insulin secretion from pancreatic β-cells.
    Authors: Nagata Et al.
    Sci Rep  2019;9:16438
  2. Dual effects of 5-HT(1a) receptor activation on breathing in neonatal mice.
    Authors: Corcoran Et al.
    J Neurosci  2014;34:51
  3. Serotonergic hallucinogens differentially modify gamma and high frequency oscillations in the rat nucleus accumbens.
    Authors: Goda Et al.
    Psychopharmacology (Berl)  2013;228:271
  4. Reduced levels of serotonin 2A receptors underlie resistance of Egr3-deficient mice to locomotor suppression by cloz.
    Authors: Williams Et al.
    Neuropsychopharmacology  2012;37:2285
  5. LSD but not lisuride disrupts prepulse inhibition in rats by activating the 5-HT(2A) receptor.
    Authors: Halberstadt and Geyer
    Psychopharmacology (Berl)  2010;208:179
  6. Raphé neurons stimulate respiratory circuit activity by multiple mechanisms via endogenously released serotonin and substance P.
    Authors: Ptak Et al.
    Biomol Ther (Seoul)  2009;29:3720
  7. Transgenic mice lacking serotonin neurons have severe apnea and high mortality during development.
    Authors: Hodges Et al.
    J Neurosci  2009;29:10341
  8. 5-HT2C-like receptors in the brain of Xenopus laevis initiate sex-typical fictive vocalizations.
    Authors: Yu and Yamaguchi
    J Neurophysiol  2009;102:752

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