MDL 100907
Chemical Name: (R)-(+)-α-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperinemethanol
Purity: ≥98%
Biological Activity
MDL 100907 is a potent and selective 5-HT2A receptor antagonist (Ki = 0.36 nM, IC50 = 3.3-5.1 nM). MDL 100907 exhibits > 80-fold selectivity for 5-HT2A receptors over other serotonergic receptor subtypes. MDL 100907 is neuroprotective; protects cultured dopaminergic neurons from MPP+ induced toxicity. Antipsychotic agent in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile.
Kehne et al.
J.Pharmacol., 1996;277:968 -
Characterization of the 5-HT2 receptor antagonist MDL 100907 as a putative atypical antipsychotic: behavioral, electrophysiological and neurochemical studies.
Sorensen et al.
J.Pharmacol.Exp.Ther., 1993;266:684 -
The 5-hydroxytryptamine2A receptor antagonist R-(+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl-4-piperidinemethanol (M100907) attenuates impulsivity after both drug-induced disruption (dizocilpine) and enhancement (antidepressant dr
Ardayfio et al.
J.Pharmacol.Exp.Ther., 2008;327:891
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Citations for MDL 100907
The citations listed below are publications that use Tocris products. Selected citations for MDL 100907 include:
11 Citations: Showing 1 - 10
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Targeting 5-HT2A receptors and Kv7 channels in PFC to attenuate chronic neuropathic pain in rats using a spared nerve injury model.
Authors: Kara R Et al.
Neurosci Lett 2022;789:136864
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Pimavanserin, a 5HT 2A receptor inverse agonist, rapidly suppresses Aβ production and related pathology in a mouse model of Alzheimer's disease.
Authors: Yuede Et al.
J.Neurochem. 2021;156:658
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Dorsal raphe nucleus to anterior cingulate cortex 5-HTergic neural circuit modulates consolation and sociability.
Authors: Rui Et al.
Elife 2021;10
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A neural circuit for comorbid depressive symptoms in chronic pain.
Authors: Zhou Et al.
Nat Neurosci 2019;22:1649
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Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells.
Authors: Alharris Et al.
Oncotarget 2019;10:45
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A Discrete Dorsal Raphe to Basal Amygdala 5-HT Circuit Calibrates Aversive Memory.
Authors: Andrew Et al.
Neuron 2019;103:489-505.e7
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Serotonin enhances excitability and gamma frequency temporal integration in mouse prefrontal fast-spiking interneurons.
Authors: Athilingam Et al.
Elife 2017;6
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Heterodimers of serotonin receptor subtypes 2 are driven by 5-HT2C protomers.
Authors: Moutkine Et al.
J Biol Chem 2017;292:6352
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Sleep Homeostatic and Waking Behavioral Phenotypes in Egr3-Deficient Mice Associated with Serotonin Receptor 5-HT2 Deficits.
Authors: Grønli Et al.
Sleep 2016;39:2189
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Increased serotonin transporter expression reduces fear and recruitment of parvalbumin interneurons of the amygdala.
Authors: Bocchio Et al.
Neuropsychopharmacology 2015;40:3015
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Essential role of brain-derived neurotrophic factor in the regulation of serotonin transmission in the basolateral amygdala.
Authors: Daftary Et al.
Neuroscience 2012;224:125
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