Mdivi 1

Biological Activity

Mdivi 1 is a selective inhibitor of dynamin GTPase (IC₅₀ = 1 - 10 μM); attenuates Dnm1- and Drp1-mediated mitochondrial division. Mdivi 1 inhibits mitochondrial outer membrane permeabilization (MOMP) and attenuates apoptosis. In cancer cell lines, Mdivi 1 reduces cell proliferation; in an animal model of ischemic retina Mdivi 1 treatment blocks apoptosis. In a cell model, Mdivi 1 protects against mutant huntington-induced damage and mitochondrial dysfunction. Mdivi 1 also inhibits autophagy and protects neurons from excitotoxicity.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles.
   Galluzzi et al.
   Nat.Rev.Drug.Discov., 2017;
2. A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis.
   Tanaka and Youle
   Mol.Cell, 2008;29:409
3. Small molecule inhibitors of mitochondrial division: tools that translate basic biological research into medicine.
   Lackner et al.
   Chem.Biol., 2010;17:57
4. Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization.
   Cassidy-Stone et al.
   Develop.Cell, 2008;14:193

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