Mdivi 1
Chemical Name: 3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone
Purity: ≥98%
Biological Activity
Mdivi 1 is a selective inhibitor of dynamin GTPase (IC50 = 1 - 10 μM); attenuates Dnm1- and Drp1-mediated mitochondrial division. Mdivi 1 inhibits mitochondrial outer membrane permeabilization (MOMP) and attenuates apoptosis. In cancer cell lines, Mdivi 1 reduces cell proliferation; in an animal model of ischemic retina Mdivi 1 treatment blocks apoptosis. In a cell model, Mdivi 1 protects against mutant huntington-induced damage and mitochondrial dysfunction. Mdivi 1 also inhibits autophagy and protects neurons from excitotoxicity.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles.
Galluzzi et al.
Nat.Rev.Drug.Discov., 2017; -
A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis.
Tanaka and Youle
Mol.Cell, 2008;29:409 -
Small molecule inhibitors of mitochondrial division: tools that translate basic biological research into medicine.
Lackner et al.
Chem.Biol., 2010;17:57 -
Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization.
Cassidy-Stone et al.
Develop.Cell, 2008;14:193
Product Datasheets
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Citations for Mdivi 1
The citations listed below are publications that use Tocris products. Selected citations for Mdivi 1 include:
7 Citations: Showing 1 - 7
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Mdivi-1 attenuates oxidative stress and exerts vascular protection in ischemic/hypoxic injury by a mechanism independent of Drp1 GTPase activity.
Authors: Tao Et al.
Redox Biol 2020;37:101706
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Saikosaponin-d, a calcium mobilizing agent, sensitizes chemoresistant ovarian cancer cells to cisplatin-induced apoptosis by facilitating mitochondrial fission and G2/M arrest.
Authors: Tsuyoshi Et al.
Oncotarget 2017;8:99825
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Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages.
Authors: Bernhard Et al.
Cell Host Microbe 2017;22:302-316.e7
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Mdivi-1 attenuates sodium azide-induced apoptosis in H9c2 cardiac muscle cells.
Authors: Xu Et al.
Mol Med Rep 2017;16:5972
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Oxidative stress-induced mitochondrial fragmentation and movement in skeletal muscle myoblasts.
Authors: Iqbal
Am J Physiol Cell Physiol 2014;306:C1176
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Attenuation of doxorubicin-induced cardiotoxicity by mdivi-1: a mitochondrial division/mitophagy inhibitor.
Authors: Gharanei Et al.
PLoS One 2013;8:e77713
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Dynamin-related protein-1 controls fusion pore dynamics during platelet granule exocytosis.
Authors: Joseph E Et al.
Arterioscler Thromb Vasc Biol 2013;33:481-8
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