McN-A 343
Chemical Name: 4-[[[(3-Chlorophenyl)amino]carbonyl]oxy]-N,N,N-trimethyl-2-butyn-1-aminium chloride
Purity: ≥99%
Biological Activity
McN-A 343 is a selective muscarinic M1 receptor agonist. Selectivity for M1 over other muscarinic receptor types appears to arise from a high efficacy at M1 receptors.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Muscarinic receptor subtypes and smooth muscle function.
Eglen et al.
Pharmacol.Rev., 1996;48:531 -
Inhibition of field stimulation-induced contractions of rabbit vas deferens by muscarinic receptor agonists: selectivity of McN-A-343 for M1 receptors.
Davies et al.
J.Pharm.Pharmacol., 2001;53:487 -
Functional determination of McN-A-343 affinity for M1 muscarinic receptors.
Micheletti and Schiavone
J.Pharmacol.Exp.Ther., 1990;253:310
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Citations for McN-A 343
The citations listed below are publications that use Tocris products. Selected citations for McN-A 343 include:
2 Citations: Showing 1 - 2
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Label-free cell phenotypic assessment of the biased agonism and efficacy of agonists at the endogenous muscarinic M3 receptors.
Authors: Deng Et al.
J Pharmacol Toxicol Methods 2013;68:323
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Inactivation of JAK2/STAT3 signaling axis and downregulation of M1 mAChR cause cognitive impairment in klotho mutant mice, a genetic model of aging.
Authors: Park Et al.
Korean J Anesthesiol 2013;38:1426
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