MCH (human, mouse, rat)

Catalog #: 3806
6 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
3806/100U

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Description: Potent endogenous MCH agonist

Alternative Names: Melanin-concentrating hormone (human,mouse,rat)

Purity: ≥95%

View All Products for Melanin-concentrating Hormone Receptor Agonists

Product Details

Citations (6)

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

MCH (human, mouse, rat) is a potent endogenous agonist at melanin-concentration hormone (MCH) receptors (IC₅₀ values are 0.3 and 1.5 nM and EC₅₀ values are 3.9 and 0.1 nM at MCH₁ and MCH₂ receptors respectively). Increases food intake in vivo.

Technical Data

M.Wt:

2386.84

Formula:

C₁₀₅H₁₆₀N₃₀O₂₆S₄

Sequence:

DFDMLRCMLGRVYRPCWQV

(Modification: Disulfide bridge: 7-16)

Solubility:

Soluble to 1 mg/ml in water

Purity:

≥95%

Storage:

Store at -20°C

CAS No:

128315-56-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R.
Sailer et al.
Proc.Natl.Acad.Sci.USA, 2001;98:7564

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M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for MCH (human, mouse, rat)

The citations listed below are publications that use Tocris products. Selected citations for MCH (human, mouse, rat) include:

6 Citations: Showing 1 - 6

Loss of hypothalamic MCH decreases food intake in amyotrophic lateral sclerosis.
Authors: Kazumoto Et al.
Acta Neuropathol 2023;145:773-791
Intranasal Administration of Melanin-Concentrating Hormone Reduces Stress-Induced Anxiety- and Depressive-Like Behaviors in Rodents.
Authors: Hi-Joon Et al.
Exp Neurobiol 2020;29:453-469
Acupuncture Alleviates Levodopa-Induced Dyskinesia via Melanin-Concentrating Hormone in Pitx3-Deficient aphakia and 6-Hydroxydopamine-Lesioned Mice.
Authors: Hi-Joon Et al.
Mol Neurobiol 2019;56:2408-2423
Novel analgesic effects of melanin-concentrating hormone on persistent neuropathic and inflammatory pain in mice.
Authors: Jang
Sci Rep 2018;8(1):707
The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW.
Authors: Nøhr Et al.
Neurochem Int 2017;102:105
Functional Connectivity of Basolateral Amygdala Neurons Carrying Orexin Receptors and Melanin-concentrating Hormone Receptors in Regulating Sociability and Mood-related Behaviors.
Authors: Kim and Han
Exp Neurobiol 2016;25:307

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