LY 341495 disodium salt
Chemical Name: (2S)-2-Amino-2-[(1S,2S)-2-carboxycycloprop-1-yl]-3-(xanth-9-yl) propanoic acid disodium salt
Purity: ≥97%
Biological Activity
LY 341495 disodium salt is a Highly potent and selective group II metabotropic glutamate receptor antagonist. Disodium salt of LY 341495 (Cat. No. 1209).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mGlu receptors in hippocampal synaptic plasticity.
Fitzjohn et al.
Neuropharmacology, 1998;37:1445 -
[3H]-LY341495 as a novel antagonist radioligand for group II metabotropic glutamate receptors: characterization of binding to membranes of mGlu receptor subtype expressing cells.
Johnson et al.
Neuropharmacology, 1999;38:1519 -
2-Substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl) glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 2. Effects of aromatic substitution, pharmacological characterization, and bioav
Ornstein et al.
J.Med.Chem., 1998;41:358
Product Datasheets
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Citations for LY 341495 disodium salt
The citations listed below are publications that use Tocris products. Selected citations for LY 341495 disodium salt include:
8 Citations: Showing 1 - 8
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Dopamine activates astrocytes in prefrontal cortex via α1-adrenergic receptors.
Authors: Kira E Et al.
Cell Rep 2022;40:111426
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Agonists and allosteric modulators promote signaling from different metabotropic glutamate receptor 5 conformations.
Authors: Jean-Philippe Et al.
Cell Rep 2021;36:109648
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Local Efficacy of Glutamate Uptake Decreases with Synapse Size.
Authors: Michel K Et al.
Cell Rep 2020;32:108182
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Site-Specific Incorporation of Genetically Encoded Photo-Crosslinkers Locates the Heteromeric Interface of a GPCR Complex in Living Cells.
Authors: Javier Et al.
Cell Chem Biol 2020;27:1308-1317.e4
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Distinct Modes of Presynaptic Inhibition of Cutaneous Afferents and Their Functions in Behavior.
Authors: David D Et al.
Neuron 2019;102:420-434.e8
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Neural Mechanisms Mediating Motion Sensitivity in Parasol Ganglion Cells of the Primate Retina.
Authors: Manookin Et al.
Neuron 2018;97:1327
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Activity-dependent astrocyte swelling is mediated by pH-regulating mechanisms.
Authors: Nanna Et al.
Glia 2017;65:1668-1681
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Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli.
Authors: Ilatovskaya Et al.
Am J Physiol Cell Physiol 2013;305:C1050
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